The Top 3 Anti-Aging Supplements

Maylin Rodriguez-Paez, RN

It’s no coincidence that our name is Life Extension. Our sole purpose is to find ways to extend the healthy, human life span. And if you haven’t noticed yet, it really is our passion.

Of course, eating healthy and exercising are top priorities for any anti-aging program, but we think there’s more to the story than that.

Nature has given us additional “tools” in the form of antioxidants to help fight and even reverse aging. As such, it’s no surprise that exploring them in depth has been a major focal point of ours for decades.

So what are our “favorite” antioxidants for helping to slow the aging process after all of these years? Below, we’ll dive into three key supplements that may just deserve this highly-coveted status.

First Things First: Why Do we Age?

Scientists aren’t exactly sure why we age, but multiple theories exist. One is the mitochondrial theory of aging. It states that the root cause of aging is oxidative stress to the mitochondria.

Mitochondria are the energy powerhouses of cells. Their job is to produce ATP (adenosine tri-phosphate), the energy currency of all cells. During production, however, free radicals are formed, an effect that damages mitochondria.

Through time, the mitochondria in your cells “take a beating” … their numbers eventually decrease, making you vulnerable to the effects of aging and disease. In fact, many diseases we associate with growing old (type II diabetes, Alzheimer’s, heart failure, and cancer1-5) are actually associated with mitochondrial dysfunction.

Luckily, certain nutrients can help.

CoQ10 Extends the Lives of Animals

A house can’t run without energy, and neither can your body. That’s where CoQ10 comes into play. This vitamin-like substance helps the mitochondria “burn fuel” more effectively. It helps the energy transfer needed to make ATP. Without it, mitochondria become dysfunctional and aging accelerates.6

CoQ10 supplementation has been shown to extend the lives of different species. It lowers the oxidative stress inflicted on mitochondria. In one study, mice given CoQ10 lived 11.7% years longer,7 which is approximately 9 human extra years based on today’s life expectancy (78.5 years).

PQQ Helps Grow New Mitochondria

PQQ is an antioxidant found in all plants. Animals need it for growth and reproduction. Like CoQ10, it helps the energy transfer process of mitochondria. But there’s one thing that makes it very unique and important: it increases the number of mitochondria in cells.8

Studies show, animals deprived of PQQ present stunted growth, decreased immune function, and fewer mitochondria in their tissue.9-11 When given PQQ, these effects are reversed.

PQQ is also one of the strongest antioxidants around, hands down. It’s actually about 5,000 times more powerful at withstanding oxidation than vitamin C.12

Carnitine Decreases Death Rates

Carnitine is nearly found in all cells in the human body. It transports fats to the mitochondria where they’re “burned” for energy. With age, carnitine levels drop significantly leaving the mitochondria vulnerable to destruction.

Carnitine guards nerve cells against damage. A particular form called acetyl-L-carnitine (ALCAR) prevents the accumulation of amyloid plaque, an abnormal protein implicated in Alzheimer’s disease.13 It also enhances cognition. In different studies, elderly people taking ALCAR show improved memory and mental status scores.14-15

Your heart needs carnitine to function optimally. Decreased levels weaken the heart, compromising function. In one study, heart attack survivors taking carnitine showed decreased blood pressure levels, improved lipids, and a decreased death rate compared to a placebo group (12.5% versus 1.2%).16

The Bottom Line

Aging starts at the cellular level — what we see on the outside is only a very small part of the picture. Powerful antioxidants such as Carnitine, PQQ, and CoQ10 have proven to be strong allies for optimizing cellular energy, which may very well be the key to living a long and healthy life.

Are you supplementing with these three antioxidants? We certainly are!


  1. Cardiovasc Res. 2010 Nov 1;88(2):229-40.
  2. Exp Physiol. 2007 Mar;92(2):333-9.
  3. J Mol Cell Cardiol. 2001 Jun;33(6):1065-89.
  4. Prog Neuropsychopharmacol Biol Psychiatry. 2011 Mar 30;35(2):320-30.
  5. Ann N Y Acad Sci. 2006 May;1067:182-90.
  6. J Biol Chem. 1997 Aug 1;272(31):19199-204.
  7. Exp Gerontol. 2004 Feb;39(2):189-94.
  8. J Biol Chem. 2010 Jan 1;285:142-52.
  9. J Nutr. 2006 Feb;136(2):390-6.
  10. Exp Biol Med (Maywood). 2003 Feb;228(2):160-6.
  11. Biochim Biophys Acta. 2006 Nov;1760(11):1741-8.
  12. Altern Med Rev. 2009 Sep;14(3):268-77.
  13. Rejuvenation Res.2011 Dec;14(6):669-79.
  14. Drugs Exp Clin Res.1994;20(4):169-76.
  15. Ann N Y Acad Sci.2004 Nov;1033:108-16.
  16. Drugs Exp Clin Res.1992;18(8):355-65.

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Face Lift said...

Thank you Maylin for this very informative post! Aging is a normal process in everyone's life, and we cannot avoid this to happen. But at least, slowing the process will do. That is why I really love to read tips and ideas on how to alter skin aging.

Life Extension said...

You're welcome! Thanks for reading.

Stephen in Birmingham said...

I hope that I don't come off as ignorant from this comment, but I have a lot to learn when it comes to antioxidants and supplements. That being said, I was wondering what's the best way to get more CoQ10 and carnitine in the system? Are there supplements that provide both?

Life Extension said...

Stephen in Birmingham- The best way to get more CoQ10 and carnitine in your system is to take them in supplement form.

noelle federico said...

The top three anti aging supplements will really help as you described above in the blog. As i am reading your blog it looks very informative blog which clears my mind that we can retain our youthful look with these top three anti aging supplements.

Life Extension said...

noelle federico - Thanks for stopping by!

Debb McHugh said...

I'm feeling confident that I don't look, my age, however, my fingers, wrist and shoulders make me feel 90. I've taken your supplements for numerous yrs, calling for advise on your Advise lines (thank you all very much), however, I cannot find the right recipe of things. Arthritis, carpel tunnel and possibly neuropathy (45yrs of Type 1) seem to get in the way... regular MDs do nothing but Rx w/bad drugs.

Life Extension said...

Debb McHugh - Sorry you're not feeling your best. Have you looked at our arthritis protocol? You may find useful suggestions there. For one, curcumin has helped many people with joint discomfort.

Amelia said...

Thanks for the great article Life Extensionists are at the forefront when it comes to taking protective measures against the physical and mental decline that occurs with aging. While many individuals faced with the prospect of aging are consistent users of antioxidants, those who are serious about extending their lives avail themselves of additional advanced anti-aging supplements as well as hormones to compensate for age-related deficits.

Life Extension said...

Amelia - We value your wonderful input! Thank YOU for reading. :-)

David said...

These all relate to mitochondria, and that's great, but no mention of telomeres. Shouldn't resveratrol and the like - something that prevents their shortening as we age - be in the top tier? Vigorous exercise - no, not a supplement - as a stimulant to mitochondrial development is seldom discussed but is part of our evolutionary biology.

Rick Tufts said...

I really think Vitamin C should be in there.

Unveil B3 said...

As a skincare therapist first thing that they teach in school, is that the sun causes 90% of premature aging on the skin.. Unfortunately as we age, the skin's overall function slows and we don't create much of the things that we need to keep skin hydrated, plumped and wrinkle free. You have to give the skin the supplements that it needs to stay young and hydrated.

Life Extension said...

David - Good points. We focused specifically on mitochondrial function, but yes vigorous exercise and resveratrol have anti-aging properties as well.

Life Extension said...

Unveil B3 - Great skin starts from the inside. CoQ10, for example, has anti-aging properties on the skin.

Resveratrol Supplements said...

Resveratrol is another nutritional supplement that has the potential to provide amazing health benefits such as anti-aging benefits. Visit to find out more about resveratrol supplements. said...

The blog is discussing important and informative matter i.e. anti aging. You described the top three anti aging supplements in your blog will really help people to retain their young look.

Mudassar Mughal said...

Well, we are all human. I haven't met a perfect one yet and the beauty of life is that when and if we do get out of balance a bit, we can get refocused and rebalanced. And I do believe that taking care of our physical body is just as important as the mental, emotional, anti aging and spiritual aspects of our lives

Helen Glen said...

Resources like the one you mentioned here will be very useful to me! I will post a link to this page on my blog. I am sure my visitors will find that very useful.

Life Extension said...

Helen Glen - Thanks! We appreciate the share.

michdad1 said...

I see no mention of Astragaloside IV. The lengthening of the Telomeres would have dramatic impact anti-aging.

RaviK said...

Can you explain the reasons given in this article about the dangers of carnitine. I am confused

Terrie | Dermology said...

Thanks for the informative post, I've never used anti aging supplements yet but it truly helpful to me. I would like to also add dermology anti aging cream as an effective anti aging solution that’s works naturally on your signs of aging.

Helen said...

Resources like the one you mentioned here will be very useful to me!
I will post a link to this page on my blog. I am sure my visitors will find that very useful.

Barry Willson said...

Nice to find the post related to my searching criteria.

Marco said...

very interesting article on anti aging, i am actually going to print it for a second read ! because i think i haven't understood everything yet ;)

Madison Wilson said...

Interesting share. Aging is faced by everyone in their life cycle where we can only control the time only. These supplements seems effective to protect our self for at least some time.

Matt said...

I have been taking CoQ10 and Carnitine for years now and I have noticed an increase in natural energy every since. Now if we could only slow down the free radicals we would age much slower :)

Life Extension said...

Matt - Extra energy is an added plus from these nutrients. Thanks for your input!

zee maya said...

Very Informative feature in your post. You highlighted many important points in it. I learn many new stuff right here. Thank you.

Life Extension said...

zee maya - Thanks for reading!

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